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بیست و نهمین کنفرانس شیمی آلی ایران
THE SYNTHESIS OF FAP-2286 ACETATE AS A PEPTIDE RADIOPHARMACEUTICAL FOR THE DIAGNOSIS AND TARGETED THERAPHY OF 30 TYPES OF CANCER TUMORS
نویسندگان :
Seyyed Mohammad Shahcheragh ( دانشگاه خوارزمی ) , Maryam Khoshdoun ( پژوهشگاه شیمی و مهندسی شیمی ایران ) , Arsalan Pashapour ( انستیتو پاستور )
کلید واژه ها :
Targeted Therapy،Peptide،Radiopharmaceuticals،Cancer
چکیده مقاله :
Fibroblast activation protein (FAP) is a membrane-bound protease that has limited expression in normal adult tissues but is highly expressed in the tumor microenvironment of many solid cancers. Currently, FAP family radiopharmaceuticals are considered the most unique and effective radiopharmaceuticals in the world in terms of their scope of action, and this active substance is used as a radiopharmaceutical in the diagnosis and treatment of 30 different types of cancer tumors [1]. In this article, the Fap-2286 acetate, which is a cyclic peptide with a complex structure, has been synthesized using a creative method. The synthesis of this structure has been done by performing the reaction on the solid phase, as shown as in Figure 1. After obtaining crude reaction, the final product was purified through preparative HPLC and identified by mass analysis. Also, its purity percentage was determined by analytical HPLC on C18 column. The preclinical and clinical studies of this peptide are currently being conducted at the Atomic Energy Organization of Iran.
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