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بیست و نهمین کنفرانس شیمی آلی ایران
A NEW APPROACH FOR IMPROVING WATER SOLUBILITY OF PROGESTERONE BY ENCAPSULATION WITH CARBOXYMETHYL-β-CD
نویسندگان :
Mehrdad Hadadian ( Hakim sabzevari university ) , Reza Allahyari ( Hakim sabzevari university ) , Behnam Mahdavi ( Hakim sabzevari university )
کلید واژه ها :
cyclodextrin،encapsulation،progesterone،inclusion complex
چکیده مقاله :
Progesterone is a steroid hormone mainly associated with female reproductive functions and formulated to treat sexually transmitted diseases and nervous disorders. However, its low water solubility limits its absorption and bioavailability. So, the formation of inclusion complexes with cyclodextrins is an excellent way to improve its solubility. For this purpose, progesterone was encapsulated in carboxymethyl-β-cyclodextrin (CM-β-CD). UV-Vis, FT-IR, and XRD analyses were performed to characterize the formed inclusion complex.
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