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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
A Novel and Efficient Procedure for the Synthesis of Spiro[acridine-9,3'-indoline]-1,2'-dione
نویسندگان :
Neda Khedri ( دانشگاه خلیج فارس ) , Mohammad reza Mohammadizadeh ( دانشگاه خلیج فارس ) , Forough Zahedpour ( دانشگاه خلیج فارس ) , Zahra Rastipour ( دانشگاه خلیج فارس )
کلید واژه ها :
Isatin،N-aryl enaminones،spiro[acridine-9,3'-indoline]-1,2'-diones
چکیده مقاله :
New drug discovery and development continues to be an area of intensive investigation. Acridine scaffold has highly efficient anti-inflammatory, anticancer, antimicrobial, antitubercular, antiparasitic, antimalarial, antiviral and fungicidal activities [1]. Furthermore, the spirocyclic oxindoles exhibit diverse biological activities including anticancer potentials [2]. In continues of our studies on the synthesis of spiro-heterocyclic compounds [3], we recently investigated the reaction of N-substituted isatin and N-aryl-enaminones, which led to introduction of a new and efficient method for the synthesis of spiro [acridine-9-3'-indoline]-1, 2'-dione derivatives. The reactions were carried out in acetic acid under reflux conditions and the desired products obtained in excellent yields (Scheme 1).
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