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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
Biosynthesis of pH-responsive magnetic nanocomposite hydrogels based on biopolymers/M-Ag bio nanoparticles: Antibacterial carrier for potential targeted anticancer drug delivery
نویسندگان :
Roghayeh Fathi ( دانشگاه تبریز ) , Reza Mohammadi ( دانشگاه تبریز )
کلید واژه ها :
Chitosan،Drug delivery،Antibacterial
چکیده مقاله :
Today, the antimicrobial activity of various nanoparticles such as Fe3O4, CuO, ZnO, Au, Ag, etc. is well known. Among the various metals, silver (Ag), particularly silver nanoparticles (Ag NPS), exhibits significant antiviral, antimicrobial, and biocompatible properties, showing great potential for biomedical applications. Until now, the green synthesis of Ag NPS has been reported using a wide range of plant extracts, bio-based sources, and microorganisms [1-2]. This study reports the development of new pH-responsive drug delivery systems that are important for the treatment of cancer. First, the Mentha plant extract was obtained and then used for the biosynthesis of magnetic Ag bio nanoparticles (M-Ag bio-NPs). They were added in the formulation of hybrid hydrogel of k-carrageenan (k-Cr) and chitosan (CS) toward the synthesis of magnetic nanocomposite hydrogels [3-4]. Their chemical structure and morphology were characterized by different analyses. Doxorubicin (DOX) was used as a model anticancer drug to study the targeted drug release behavior of the synthesized nanocomposite hydrogels (loading capacity (about 98%). In vitro drug release studies showed that the release profile was noticeably controlled in a pH-dependent manner (higher drug release at pH 5). The antibacterial assessment confirmed the high antibacterial activity for the synthesized hydrogel against S. aureus (MIC values 39.06 µg/mL) and E. coli (MIC values > 19.53). In-vitro cytotoxicity results (MTT assay) demonstrated good biocompatibility (higher than 88%) for the blank nanocomposite hydrogels, while DOX-loaded nanocomposite hydrogels showed high toxicity (about 22% in the concentration of 20 µg/mL) against HeLa cells. The results showed that the present nanocomposite hydrogels can be suggested for potential application as an antibacterial and anticancer carrier.
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