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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
Green synthesis of pH-responsive nanocomposite hydrogels based on biopolymers/LDH bio nanoparticles: for potential targeted anticancer drug delivery
نویسندگان :
Roghayeh Fathi ( دانشگاه تبریز ) , Reza Mohammadi ( دانشگاه تبریز )
کلید واژه ها :
Biosynthesis،LDH،Drug delivery
چکیده مقاله :
There are many medicinal plants in Iranian traditional medicine with significant therapeutic properties. Among the various biological sources, plant extracts are safe, easily available, biocompatible, and provide good control over morphology and resistance [1]. Layered double hydroxides (LDHs) are an emergent class of inorganic lamellar nanomaterials having a 2D structure and belong to the class of hydrotalcite or anionic clays [2]. LDH is a good carrier for drug and gene delivery. It can carry the drug and delay its release. The drugs intercalated within LDH will be releasing slowly and thereby the frequency of administration of drugs can be decreased LDH is a good carrier for drug and gene delivery. It can carry the drug and delay its release. The drugs intercalated within LDH will be releasing slowly and thereby the frequency of administration of drugs can be decreased [3]. This study reports the development of new pH-responsive drug delivery systems that are important for the treatment of cancer. First, the Mentha plant extract was obtained and then used for the biosynthesis of LDH (Al/Zn) bio nanoparticles. They were added in the formulation of hybrid hydrogel of chitosan and pectin toward the synthesis of nanocomposite hydrogels. Their chemical structure and morphology were characterized by FT-IR, XRD, SEM and EDS analyses. Doxorubicin was used as a model anticancer drug to study the targeted drug release behavior of the synthesized nanocomposite hydrogels (pre-loading capacity (about 96%)). In vitro drug release studies showed that the release profile was noticeably controlled in a pH-dependent manner (higher drug release at pH 7/4). In-vitro cytotoxicity results (MTT assay) demonstrated good biocompatibility (higher than 86%) for the blank nanocomposite hydrogels, while DOX-loaded nanocomposite hydrogels showed high toxicity (about 25% in the concentration of 20 µg/mL) against HeLa cells. The results showed that the present nanocomposite hydrogels can be suggested for potential application as an anticancer carrier for oral delivery systems.
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