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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
Electrochemical Study of Mefenamic Acid in the Presence of Coumarin Derivatives to Synthesis of New Organic Compounds
نویسندگان :
Mobina Hajihosini ( دانشگاه بوعلی سینا ) , Sadegh Khazalpour ( دانشگاه بوعلی سینا ) , Maryam Mehrdadian ( دانشگاه بوعلی سینا ) , Ameneh Amani ( دانشگاه نهاوند (ویژه دختران) )
کلید واژه ها :
Mefenamic acid،Coumarin،Electrochemical
چکیده مقاله :
Mefenamic acid (MFA) belongs to N-aryl anthranilic acid, which includes non-steroidal anti-inflammatory drugs (NSAIDs) that are widely used today. It is used in the treatment of pain, arthritis and dysmenorrhea. MFA has been used for hepatotoxicity, renal toxicity, gastrointestinal toxicity, hypersensitivity reactions caused by the formation of reactive metabolites such as carboxyl group containing NSAIDs and reactive protein [1]. Long-term use of this drug also causes some serious problems, including: stomach cramps, vomiting, constipation, heart attack, stroke, stomach ulcers, liver problems, kidney failure [2]. Coumarins are polyphenolic compounds [3]. This group is anti-inflammatory, anti-convulsing, anti-viral, anti-coagulant, anti-oxidant, anti-microbial, anti-tuberculosis, anti-allergic, anti-fungal, anti-HIV and anti-cancer and is also used to prevent the accumulation of platelets [4]. Considering the unique properties of mefenamic acid and the specific properties of coumarins, we decided to synthesize a compound that includes both functional groups. In this work, the electrochemical oxidation of mefenamic acid has been investigated in the presence of coumarin derivatives as nucleophiles. Based on the obtained results from voltammetry data, new products are synthesized in ethanol/aqueous buffer solution (pH=10) (70/30) by controlled potential method. In final, the formation of the product was confirmed using NMR, MS and IR spectra.
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