0% Complete
صفحه اصلی
/
بیست و نهمین کنفرانس شیمی آلی ایران
Magnetic starch as support for the growth of hyaluronic acid terminated covalent organic framework: A pH-controlled drug carrier
نویسندگان :
Malihe Pooresmaeil ( دانشگاه تبریز ) , Hassan Namazi ( دانشگاه تبریز )
کلید واژه ها :
Cobalt ferrite،Starch،Covalent organic framework،Hyaluronic acid،Daunorubicin
چکیده مقاله :
Cancer is one of the greatest fearsome diseases with the leading cause of death that results because of the uncontrolled growth of cells [1]. In recent years the development of nanomaterials has taken new chances and challenges in numerous aspects so there is no doubt that these materials accomplish well in tumor therapy [2-3]. Therefore, herein, a new multifunctional nanosystem was designed and fabricated benefiting from the cobalt ferrite nanoparticles (CoFe2O4), starch (St), covalent organic framework (COF), and hyaluronic acid (HA) features. The outcomes of the explored physicochemical properties confirmed the success of the DNR@CoFe2O4@St@COF(DtTb)-HA synthesis. BET analysis obtained the surface area and mean pore diameter respectively 55.458 m2 g-1 and 6.3855 nm. Daunorubicin as a model anticancer drug was loaded into the final system. The release pattern revealed the enhanced drug release in simulated tumor cell conditions. More importantly, the outcome of the MTT, DAPI, and cell cycle tests as the important aspect of toxicological assessments exhibited that the CoFe2O4@St@COF(DtTb)-HA is biocompatible, while the drug-loaded system leads to further inhibition of cell proliferation.
لیست مقالات این رویداد
ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها
