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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
Carboxymethyl starch-gelatin coated COF/5-Fu as pH-sensitive drug delivery vehicle
نویسندگان :
Malihe Pooresmaeil ( دانشگاه تبریز ) , Hassan Namazi ( دانشگاه تبریز )
کلید واژه ها :
Covalent organic framework،Carboxymethyl starch،Gelatin،pH-responsive system
چکیده مقاله :
Colon cancer is one of the important cases of a risk to human health which has commonly been a major concern worldwide [1]. Therefore, today, the enormous amount of effort spent to treat it. Newly, oral drug carriers based on porous materials and polysaccharides have been recognized to be efficient in therapeutic drug delivery to the colon [2-3]. Therefore, in the current study, we constructed covalent organic framework with a spherical structure as a platform for 5-fluorouracil (5-Fu) loading at about ~93.33% (COF/5-Fu). However, their imine bond is relatively unstable in harsh acidic conditions. Hence, there is an urgent and strong need to cap COF/5-Fu into carboxymethyl starch-gelatin (CMS-Gel) coat (COF/5-Fu@CMS-Gel). Drug release tests showed that the loaded 5-Fu was released highly at pH 7.4, but only 14.11 % of 5-Fu releases occurred at pH 1.2. All together the results can guarantee that the COF/5-Fu@CMS-Gel is promising for controlled colon drug delivery.
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