0% Complete
صفحه اصلی
/
بیست و نهمین کنفرانس شیمی آلی ایران
Drug delivery and controlled release of gemcitabine in polymer nano-capsules for pancreatic cancer therapy
نویسندگان :
Amirali Rafati ( دانشگاه علوم پزشکی تهران-دانشکده پزشکی )
کلید واژه ها :
Gemcitabine،Drug delivery systems،Controlled drug release،Pancreatic cancer،Polymer nanoparticle
چکیده مقاله :
Gemcitabine is a nucleoside analogue widely used for the treatment of pancreatic cancer, but its clinical efficacy is limited by its short half-life, rapid metabolism, and drug resistance. In this study, we developed a novel drug delivery system based on polymer nanocapsules for the controlled release of gemcitabine. The polymer nanocapsules were prepared by self-assembly of poly(N-vinylcaprolactam) (PVCL) containing solid lipid polymer hybrid nanoparticles (SLPHNs) that were loaded with gemcitabine and decorated with folic acid for targeted delivery. The physicochemical properties, drug loading and release, cellular uptake, cytotoxicity, and antitumor activity of the nanocapsules were evaluated in vitro and in vivo. The results showed that the nanocapsules had a spherical shape, a mean size of about 100 nm, a high drug loading efficiency of about 80%, and a pH-responsive release profile. The nanocapsules exhibited enhanced cellular uptake and cytotoxicity against pancreatic cancer cells compared to free gemcitabine, especially in the presence of folic acid. The nanocapsules also showed superior antitumor efficacy and reduced systemic toxicity in a mouse xenograft model of pancreatic cancer. These findings suggest that the polymer nanocapsules are a promising drug delivery system for gemcitabine with improved pharmacokinetics and therapeutic outcomes.
لیست مقالات این رویداد
ثمین همایش، سامانه مدیریت کنفرانس ها و جشنواره ها
