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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
Highly regioselective tree-component synthesis of novel 4H-pyrano[2,3-b]quinoline derivatives
نویسندگان :
معصومه حیدری ( پژوهشگاه شیمی و مهندسی شیمی ایران ) , علی اصغر محمدی ( پژوهشگاه شیمی و مهندسی شیمی ایران ) , محمدرضا مصلح ( پژوهشگاه شیمی و مهندسی شیمی ایران )
کلید واژه ها :
Regioselective،Multicomponent،Metal-free،Pyranoquinoline،Heterocyclization
چکیده مقاله :
A highly regioselective multicomponent synthesis via knoevenagel condensation/heterocyclization sequence has been executed. An efficient and fast-track protocol has been used for preparing O-heterocyclic compounds under metal-free conditions. The one pot three-component reaction of 2-chloroquinoline-3-carbaldehyde and two diverse cyclic active methylenes (dimedone and barbituric acid) for the synthesis of 4H-pyrano[2,3-b]quinoline has been accomplished under mild condition. The strategy included herein shows significant advantages including a facile process with easy purification, excellent yields, wide applicability, available substrates and cost-effective and eco-friendly solvent and catalyst.
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