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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
Design, synthesis and biological activities evaluation of novel resveratrol derivatives
نویسندگان :
Abdolrasoul H. Ebrahimabadi ( دانشگاه کاشان ) , Ali Yousefi ( دانشگاه کاشان )
کلید واژه ها :
Antioxidant،Anticancer،Resveratrol،Synthesis،Cytotoxicity
چکیده مقاله :
Resveratrol is a natural phytoalexin found in grapes, pine, legumes, pomegranate, beans, soybeans and peanuts [1]. It is known as a representative of polyphenolic trans-stilbenes. Stilbenes, especially resveratrol, have shown a lot of significant biological activities such as antifungal, antimicrobial, anticancer, antiestrogen, antiplatelet aggregation, antioxidant, heart protector, antimalarial, light protector, anti-inflammatory and antipyretic [2,3]. The use of resveratrol as a potentially beneficial agent is promising. But, due to some unfavourable pharmacokinetic/pharmacodynamic characteristics such as weak bioavailability, its use is limited. This study was conducted to design, synthesize and evaluate the biological activities of new derivatives of resveratrol using the bio-isosteric concept to overcome these limitations and improve the biological effects. Three derivatives of resveratrol with spatial variation of hydroxyl groups on phenyl rings were synthesized by a new synthesis method. The chemical structures of produced products were confirmed via 1H NMR, 13C NMR, FT-IR analysis and analytical HPLC. Then important biological properties such as anti-oxidant properties with a valid DPPH test, anti-cancer properties with the brine shrimp lethality test, the cytotoxicity test with the MTT method and antimicrobial properties against various pathogenic bacteria was performed.
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