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بیست و نهمین کنفرانس شیمی آلی ایران
Synthesis of new benzo imidazole pyrrolidine carbothioate via thiol ester linkage
نویسندگان :
Zahra Ashoori ( دانشگاه بین‌المللی امام خمینی (ره) قزوین ) , Mohammad Bayat ( دانشگاه بین‌المللی امام خمینی (ره) قزوین ) , Shima Nasri ( دانشگاه بین‌المللی امام خمینی (ره) قزوین )
کلید واژه ها :
benzimidazole-2-thiol،L-proline،benzo imidazole pyrrolidine carbothioate
چکیده مقاله :
Recently, some procedures were reported for the synthesis of substituted benzoheterocycles such as benzimidazole-2-thiol which are vital blocks of some medical agents or biologically active compounds. Various derivatives of 2-mercapto benzimidazole have exhibited a wide range of biological activities such as antimicrobial, antihistamine, neutropic, and analgesic activities. Also, it serves as a plant growth regulator and is used as a corrosion inhibitor, as well as a well-known analytical reagent for mercury and some metal ions in sewage water and industrial wastewater samples. Generally, compounds containing benzimidazole-2-thiol core synthesized from alkylation of 2- mercapto benzimidazole under basic conditions using different alkyl halides and aryl halides gave the thioether derivatives. On the other hand, thioesters can be prepared by condensation of carboxylic acids with an alkali metal salt of a thiol in the presence of dehydrating agents.
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