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بیست و نهمین کنفرانس شیمی آلی ایران
Synthetic approach toward thiazolone-fused benzo imidazole scaffold using 2-benzimidazolethiol
نویسندگان :
Zahra Ashoori ( دانشگاه بین‌المللی امام خمینی (ره) قزوین ) , Mohammad Bayat ( دانشگاه بین‌المللی امام خمینی (ره) قزوین ) , Shima Nasri ( دانشگاه بین‌المللی امام خمینی (ره) قزوین )
کلید واژه ها :
2-Benzimidazolethiol،Chloroacetic acid،Thiazolone-fused benzo imidazole
چکیده مقاله :
2-Mercaptobenzimidazole is the organosulfur compound derived from benzimidazole with a thiol group in the 2-position. 2-mercaptobenzimidazole contains a thioamide group (-N-C=S), therefore it is considered one of the thioamide compounds for its ability to react under special conditions to give derivatives having a substituent at either nitrogen or sulfur atoms. The benzimidazole-2-thiol containing compounds are attractive synthetic targets due to their medicinal activity such as antibacterial agents, antifungal agents, potent anticonvulsant, antiinflammatory/analgesic agents, antimicrobial, anti-inflammatory, and analgesic agents. Some drugs such as Fabomotizole used as potent anxiolytic drugs, and 2-MBI oxadiazoles as antidiabetic agents. With this background of biological activities of mercapto benzimidazole and the necessary need for the formation of molecular architectures with wide potential biological activities, here we designed and introduced a new protocol involving the reaction of the 2-benzimidazolethiol, chloroacetic acid under mild reaction conditions leads to benzo imidazo thiazolone in good yields
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