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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
One-pot two-step synthesis of novel 4-substitiuted tetrazolo[1,5-a]quinoline derivatives via a sequential Ugi-4CR– nucleophilic substitution and intramolecular cyclization reaction
نویسندگان :
Zahra Fahimi ( داشگاه قم )
کلید واژه ها :
Quinoline derivatives،Ugi reaction،Nucleophilic addition،Intramolecular cyclization،2-Chloro-3-formyl quinoline
چکیده مقاله :
Multi-component reactions (MCRs) are powerful synthetic tools, in which more than two starting materials react with each other to form multi-functionalized compounds in a one-pot procedure. Nowadays, MCRs are an exceptional strategy to synthesize many pharmaceutical and drug-like structure compounds due to their atom economy, high efficiency, low cost and simple experimental procedure. One of the most important subsets of this group of reactions is the Ugi reaction, that become increasingly efficient in the synthesis of many natural products and macro-cyclic molecules [1]. Due to the increasing application of heterocyclic compounds, especially quinoline derivatives and compounds containing tetrazole ring [2], in this research, new derivatives of these compounds have been synthesized via one- pot two-step reactions with high efficiency
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