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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
The Mechanism investigation of Acetaminophen's Interaction with L-Cysteine and L-Methionine by Electrochemical Techniques
نویسندگان :
Shadi Moeini-Far ( University of Zanjan ) , Hassan Shayani-Jam ( University of Zanjan ) , Mohammad Reza Yaftian ( University of Zanjan )
کلید واژه ها :
Acetaminophen،Electrosynthesis،Drug Interaction،Electrochemistry
چکیده مقاله :
Electrochemistry can be a useful tool in understanding the mechanism of compound reactions in chemistry. Electrosynthesis also allows for the use of the moderate reaction conditions, reducing the need for harsh reagents or high temperatures. This can be beneficial for sensitive compounds or reactions that are difficult to achieve using traditional techniques [1, 2]. The aim of this research is performing a thorough analysis in order to determine the reaction mechanism between amino acids (L-cysteine and L-methionine) and acetaminophen by using cyclic voltammetry and coulometry techniques. The final product was synthesized using coulometry in aqueous solution through a catalyst‐free environmentally friendly method at room temperature under green conditions. The product was then separated and purified. It was characterized by NMR, FT-IR and MS techniques. The obtained results reveals N-acetyl-P-benzoquinone (NAPQI) induced by acetaminophen oxidation, can undergo reactions with L-cysteine and L-methionine. As resulting, these amino acids potentially possessing the ability to reduce or eliminate the toxicity of NAPQI (Scheme1). As a result, these amino acids can be considered as potential antidotes for acetaminophen overdoses
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