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بیست و نهمین کنفرانس شیمی آلی ایران
Synthesis of N-aryl pyrrole derivatives in the presence of titanium (IV) tetrachloride immobilized on nanocellulose
نویسندگان :
Mohsen Rostamian ( دانشگاه کاشان ) , Abdolhamid Bamoniri ( دانشگاه کاشان )
کلید واژه ها :
N-aryl pyrroles،Nanocatalyst،Aromatic amines،2,5-hexanedione
چکیده مقاله :
Undoubtedly, heterocyclic chemistry forms the largest and the most diverse family of organic chemistry. In particular, nitrogen-containing heterocyclic compounds have always played a key role in the pharmaceutical and agrochemical industries[1]. Pyrroles are the most ubiquitous heterocycles as they are found in the structural fragments of various natural products and pharmaceutical compounds. Owing to their varied pharmacological properties like antibacterial, antiviral, antioxidant, antifungal and anticancer significant efforts are directed towards development of newer protocols for the synthesis of functionalized pyrroles[2]. The most commonly method for the preparation of pyrroles is the Paal–Knor of 1,4-dicarbonyl compound with a vast variety of primary aromatic amines, which requires a special reagent or force reaction conditions[3]. Many procedures for the synthesis of N-aryl pyrroles have been reported in the presence of various catalysts. Herein, we wish report the synthesis of N-aryl pyrroles using various primary aromatic amines and 2,5-hexanedione in the presence of nanocellulose/TiCl4 as a green catalyst under different conditions (Scheme1). The advantages of this work are simple work-up, mild condition, short reaction time and high yields.
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