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صفحه اصلی
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بیست و نهمین کنفرانس شیمی آلی ایران
Core-shell Cu based metal organic framework coated with fluorouracil imprinted methacrylamid polymer :A PH-responsive anticancer nanocarrier
نویسندگان :
حسین حسین زاده ( دانشگاه تبریز )
کلید واژه ها :
molecular imprinted polymer،metal-organic frameworks،drug delivery
چکیده مقاله :
Recent research has increasingly received more attention to molecularly imprinted polymers (MIPs) and their application in the biomedical nanoplatforms [1]. In this study, an innovative fluorouracil (5-FU) imprinted polymer via the precipitation free radical polymerization strategy was developed as shell on the Cu-based metal organic framework (MOF) as core for drug delivery system. The prepared materials were characterized by different analysis such as Fourier transform infrared (FT-IR), scanning electron microscopy (SEM) and X-Ray Diffraction (XRD) . Binding kinetics of 5-FU established specific recognition binding sites in the core shell nanoscale molecularly imprinted polymer structure [1]. In vitro drug release behaviors exhibited a pH-controlled release in a indicated that a 5-FU-loaded nanocarrier against cancer cells has notable cytotoxicity. According to the obtained results, the prepared pH-responsive core shell has the potential to be employed as an anticancer drug delivery platform.[2].
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